Not seasoned here (by some people's reckoning), just two years on the road. My wife and I have never driven a manual tranny truck. We have driven class 8 trucks with the Eaton 10-speed autoshift and the Allison 6-speed automatic. The auto-shift has three pedals on the floor; the automatic just two. The Eaton requires you to use the clutch pedal whenever the truck starts or stops. The Allison automatic is just like a car's automatic transmission. With it, you can work your way through a traffic jam with your big toe.
We got better fuel economy with the 10-speed transmissions than with the 6 speed we're driving now. But boy-oh-boy, does that torque converter, 6-speed unit get the truck going from a dead stop. We can keep up with and even leave cars behind comming off a stop light if we wish. It's designed for in-town driving or for use in mines and other places where a truck under heavy load will start and stop a lot. Given the fuel economy difference, it's not the best choice for over the road work (one man's opinion).
Another factor is driver fatigue. When we got into a truck that had only two pedals on the floor, we were plesantly surprised to find we could drive longer without getting tired. A full-automatic transmission definately reduced fatigue in our case.
Another automated transmission to consider is the Arvin Meritor FreedomLine 12 speed. Can't say much about it since we've not driven one, but it gets high reviews from people who write about such things.
All automated and automatic transmissions reduce operating costs over the life cycle of the truck. Their higher front-end price pays for itself in increased fuel economy and lower stress on the drive train. The lack of a clutch in torque-converter transmissions eliminates clutch replacement costs. By taking the driver out of the gear-choice process, automatic and automated transmissions reduce wear and tear on drive train components, and thus reduce maintenance costs.
One down side of an automated or automatic transmission is putting up with the opinion of some that say you are not a "real" trucker if you dont' drive a stick.