Good advice from the other two people. But first what kind of truck do you have and call around to some of the expedite companies on this site to see if they can use your type of vehicle.
If you don't have any experience in expediting then consider driving for someone else, or hook up with a local courier company...They do get long runs too! Gain your experience then pay attention to fellow expediters on the road, talk with them ask questions read these forums.
Once you've gained the experience, and decide what size vehicle suits you (some o/o will start in one size and upgrade to another) hopefully you'll be successful...Good Luck!