I have covered this topic before, and it seems like the folks at Detroit Diesel agree with my opinions on synthetics.
Yes, they have superior lubricating qualities, and much more stable viscosity than standard mineral based oils. However, they are not going to increase your drain intervals, even though the people who make them try to tell you they do.
Most of the stuff that contaminates your oil is from blow-by. It's unburned fuel, water condensate, carbon, etc. (combustion by-products) that get forced past the end gaps in the engine's piston rings. Some of this stuff is heated up and goes out the vent in the form of gasses, other particulates are picked up in the oil filters. But still, over time, things will build up in the oil that are going to just stay. An oil analysis can tell you what they are, even tiny particles of bearing material, for instance. There is NOTHING ANY OIL can do to remove this stuff! You just have to drain and change it. And for this reason, plus the high cost of synthetics, I'd stick with good ol' Rotella.
A good place for synthetics, you ask? Gearboxes! You want them to be lubed well, have stable viscosity, and the oil stays in them for a year or more. Most tranny manufacturers require synthetic lube now.
The higher cost there is worth it.
-Weave-