My current CV has a 4.8 V8 and has 380,000 miles on it.... I run Amsoil Synthetic and nothing else...I TRY to change the filter every 5000 mile and add the required oil at that time and normally have to add a quart inbetween filter changes...I change the oil and filter together every 15,000 miles.
Now..I have just bought a new CV with a 6.0 V8. Amsoil as a "protection promise" that if you use their oil and filter and change them at 20.000 mile intervals they will warranty and "oil related" engine failures for up to 200,000 miles...I spoke to an engineering rep from Amsoil to get his suggestions as to if I should change out the OEM oil before I started OTR or wait until the 1st oil change which I would do a 3000 miles since it is a new motor...his recommendation was to run the OEM and then change it and ten follow whatever program I felt comfortable with as long as the filter and oil were both changed out within the 20,000 mile interval....I will be continuing my routine of a filter every 5000 miles and oil and filter at 15,000....it has worked fine on the motor in my current van...but i will tell you, i do miss the exact miles for change from time to time and if i let it go too long, I can see a drop in oil pressure at an idle...that won't happen on the new van....
One other thing, I also ue amsoil trans fluid and Differential gear oil and use a synthetic lube on the ft suspension parts also..