Can't speak regarding a van, not my thing, but I do fairly well running solo in a straight truck for FedEx, in that area. What helps is I have all the endorsements needed for their White Glove service. Also, my income needs are not real high. A poor week will gross 1k+ to the truck, a good week, 3k+. Average is about 2100 to 2400.
I run GA, SC, NC, VA & some TN. Also will do FL, if rate is high enough
My wife's health is why I try and stay in the area, otherwise, wouldn't be a issue.
Jim F